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Expression of Tumor-Associated Membrane Antigen, RCAS1, in Human Colorectal Carcinomas and Possible Role in Apoptosis of Tumor-Infiltrating Lymphocytes

机译:肿瘤相关膜抗原RCAS1在人大肠癌中的表达及其在肿瘤浸润淋巴细胞凋亡中的作用

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RCAS1, a novel tumor-associated antigen, is expressed in advanced human neoplasias including uterine and ovarian carcinomas. RCAS1 protein was indicated to induce cell cycle arrest and apoptosis of cultured human lymphoid and myeloid cell lines and normal lymphocytes. In the present study, we investigated the expression and prognostic value of RCAS1 in 58 patients with colorectal carcinomas. RCAS1 protein was detected by immunoperoxidase staining using a mouse monoclonal anti-RCAS1 antibody (22-1-1 antibody). Immunohistochemical examination showed expression of RCAS1 in 75% of colorectal carcinomas with lymph node metastases (n = 24), whereas it was present in only 41% of tumors without metastases (n = 34, P P P = .0300; risk ratio, 0.496). In addition, apoptotic cells of tumor-infiltrating lymphocytes were examined using nonradioactive in situ nick translation in paraffin-embedded sections. The proportion of apoptotic tumor-infiltrating lymphocytes was significantly higher in RCAS1-positive colorectal carcinomas (11.2 1.0) than in RCAS1-negative tumors (7.9 1.0, P in vivo.
机译:RCAS1是一种新型的肿瘤相关抗原,在包括子宫癌和卵巢癌在内的晚期人类肿瘤中表达。 RCAS1蛋白可诱导培养的人淋巴和髓样细胞系以及正常淋巴细胞的细胞周期停滞和凋亡。在本研究中,我们调查了RCAS1在58例大肠癌患者中的表达及其预后价值。使用小鼠单克隆抗RCAS1抗体(22-1-1抗体)通过免疫过氧化物酶染色检测RCAS1蛋白。免疫组织化学检查显示RCAS1在75%的具有淋巴结转移的大肠癌中表达(n = 24),而仅在41%的无转移的肿瘤中表达(n = 34,PPP = .0300;风险比为0.496 )。另外,在石蜡包埋的切片中使用非放射性原位切口平移检查了肿瘤浸润淋巴细胞的凋亡细胞。 RCAS1阳性结直肠癌中凋亡性肿瘤浸润淋巴细胞的比例显着高于体内RCAS1阴性肿瘤(7.9 1.0,P)。

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