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Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin

机译:p63在原发性皮肤附件肿瘤和转移至皮肤的腺癌中的表达

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p63, a recently identified homologue of the p53 gene, has been reported to be essential in the development of epithelia and is mainly expressed by basal and myoepithelial cells. The purpose of this study was to investigate the pattern of p63 expression in cutaneous adnexal neoplasms and to assess its possible value in the differential diagnosis of primary cutaneous neoplasms vs adenocarcinomas metastatic to the skin. Immunohistochemical analysis for p63 was performed on formalin-fixed, paraffin-embedded archival tissue from 20 benign adnexal tumors, 10 malignant adnexal tumors and 14 adenocarcinomas metastatic to the skin. The expression of p63 was evaluated in epidermal cells, skin appendages and metastatic tumor cells. p63 was consistently expressed in the basal and suprabasal cells of epidermis and cutaneous appendages, including the basal/myoepithelial cells of sweat glands. Out of 20 benign adnexal tumors, 13 (65%) showed strong (score 3) p63 expression; the remaining seven (35%) cases had score 2. All primary cutaneous carcinomas, including adenocarcinomas, expressed p63. In contrast, none of the metastatic adenocarcinomas to the skin was positive for p63 (Pp63 expression may help in the differential diagnosis of primary vs metastatic cutaneous adenocarcinomas.
机译:据报道,最近鉴定出的p53基因的同源物p63在上皮细胞的发育中是必不可少的,主要由基底细胞和肌上皮细胞表达。这项研究的目的是调查p63在皮肤附件肿瘤中的表达模式,并评估其在原发性皮肤肿瘤与转移至皮肤的腺癌的鉴别诊断中的可能价值。对p63的免疫组织化学分析是在福尔马林固定,石蜡包埋的存档组织上进行的,该存档组织来自20例良性附件肿瘤,10例恶性附件肿瘤和14例转移至皮肤的腺癌。在表皮细胞,皮肤附件和转移性肿瘤细胞中评估了p63的表达。 p63在表皮和皮肤附件的基底和上基底细胞(包括汗腺的基底/肌上皮细胞)中持续表达。在20例良性附件肿瘤中,有13例(65%)显示出强烈的p63表达(得分3);其余7例(35%)得分为2。所有原发性皮肤癌,包括腺癌,均表达p63。相反,皮肤上的转移性腺癌均没有p63阳性(Pp63表达可能有助于对原发性和转移性皮肤腺癌进行鉴别诊断。

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