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Histologic features are important prognostic indicators in early stages lung adenocarcinomas

机译:组织学特征是早期肺腺癌的重要预后指标

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This study attempts to evaluate the clinicopathologic features of mixed subtype adenocarcinomas and the prognostic implications of histopathology classifications. Surgical specimens from 141 patients with clinical stage I or II lung adenocarcinoma during the period 1992–2004 were included. These cases were classified into four groups defined by the extent of the bronchioloalveolar carcinoma component: group I: pure bronchioloalveolar carcinoma; group II: mixed subtype with predominant bronchioloalveolar carcinoma component and 5mm invasive component; group III: mixed subtype with bronchioloalveolar carcinoma component and >5mm invasive component; group IV: invasive carcinoma with no bronchioloalveolar carcinoma component. Descriptive statistics were used to examine the groups with respect to age, tumor size, lymph node metastasis, and Ki-67 and p53 expression levels. Death rate for the groups was obtained by patient's charts and from the National Death Index database. The population was similar in age, tumor size and lymph node metastasis. Immunohistochemical results showed that the mean Ki-67 labeling and the amount of p53 overexpression had the same trend of increasing mean values or positive results from groups I to IV. The reported proportion of deaths ranged from 0% for groups I and II, 20% in patients with predominant invasive component with bronchioloalveolar carcinoma (group III), and 18% in patients with invasive carcinomas and no bronchioloalveolar carcinoma component (group IV). The difference between the proportion of patients with reported deaths in the time period of this study in the combined greater than 5mm+pure invasive groups (groups III, IV), and the <5mm+noninvasive groups (groups I, II) is statistically significant. These results suggest that histological features may be useful in defining categories of lung adenocarcinomas with differing survival and prognostic features. These results are helpful in defining a subcategory of 'minimally invasive adenocarcinoma', which has features similar to bronchioloalveolar carcinoma.
机译:这项研究试图评估混合亚型腺癌的临床病理特征和组织病理学分类的预后意义。纳入了1992年至2004年期间来自141例临床I或II期肺腺癌患者的手术标本。根据细支气管肺泡癌成分的程度,将这些病例分为四组:第一组:纯支气管肺泡癌;第二组:主要为支气管肺泡癌成分和5mm浸润成分的混合亚型;第三组:具有支气管肺泡癌成分和> 5mm浸润成分的混合亚型;第四组:无支气管肺泡癌成分的浸润性癌。描述性统计数据用于检查年龄,肿瘤大小,淋巴结转移以及Ki-67和p53表达水平的人群。各组的死亡率通过患者病历表和国家死亡指数数据库获得。该人群的年龄,肿瘤大小和淋巴结转移情况相似。免疫组织化学结果显示,平均Ki-67标记和p53过表达量具有相同的趋势,即I至IV组均值增加或阳性结果。报告的死亡比例在第一和第二组为0%,在具有主要侵袭性支气管肺泡癌的患者中为20%(第三组)和在没有浸润性支气管肺泡癌的患者中为18%(第四组) )。大于5mm +纯创组(III,IV组)和<5mm +无创组(I,II组)在合并的大于5mm +纯创组和本研究中报告死亡的患者比例之间的差异具有统计学意义。这些结果表明,组织学特征可能有助于确定具有不同生存率和预后特征的肺腺癌的类别。这些结果有助于确定“微创腺癌”的子类别,该子类别具有与支气管肺泡癌相似的特征。

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