Interleukin-1β and Interleukin-6 in Arthritis Animal Models: Roles in the Early Phase of Transition from Acute to Chronic Inflammation and Relevance for Human Rheumatoid Arthritis

摘要

Tumor necrosis factor is the major target of therapeutic approaches in rheumatoid arthritis. A key issue in chronic arthritis is understanding the crucial molecules driving the transition from the acute phase to the chronic irreversible phase of the disease. In this review, Ferraccioli et al . examine five experimental models of rheumatoid arthritis and review cytokines necessary for driving the condition from acute to chronic.