A Superagonistic Monoclonal Antibody for CD28 Ameliorates Crescentic Glomerulonephritis in Wistar-Kyoto Rats

摘要

Regulatory T (Treg) cells play an important role in the resolution of crescentic lomerulonephritis (GN), therefore, agents that increase Treg cells appear to be ideal for suppressing T-cell-mediated renal pathology. Takabatake et al . hypothesized that a superagonistic monoclonal antibody for CD28 (CD28-SA) which has been known to preferentially expand Treg cells in vivo , could prevent nephrotoxic serum-induced crescentic GN. Administration of CD28-SA attenuated crescent formation, proteinuria, and glomerular accumulation of macrophages and CD8+ T cells. These changes were accompanied by increased infiltration of Treg cells. This study demonstrates treatment with CD28-SA has a dramatic therapeutic effect on an experimental crescentic GN, potentially due to expansion and activation of Treg cells.