The incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with the new generation of antipsychotic drugs compared to conventional therapy

摘要

Aim To investigate the incidence of dyslipidemia (hypertriglyceridemiaand hypercholesterolemia) in patients treated with antipsychoticsof new generation compared to conventional therapy.Methods This retrospective study included 116 chronic psychiatricpatients divided into two groups: a test group who wereon treatment with antipsychotics of the new generation and acontrol group who were treated with classical antipsychotics.Laboratory and vital parameters were monitored in a group ofpatients who were treated with new generation antipsychotics(clozapine, olanzapine, risperidone), as well as in the group of patientswho were treated with classical antipsychotics (promazine,levopromazin,haloperidol, fluphenazine).Results Mean triglyceride level in the test group was 3.13 mmol/L,and for the control group, 2.28 mmol/L, while the mean value forcholesterol test group was 6.12 mmol/L, and for the control group,5.85 mmol/L. The average age of the test group was 49.6 years,while the control group was 51.47 years. There was a statisticalsignificance in triglycerides (p = 0.004), while the cholesterol (p= 0.239) and age (p = 0.356) had no statistical significance in thetest group compared to the patients who were treated by the newgeneration of antipsychotics, and the control group of patients whowere treated with antipsychotics.Conclusion Dyslipidemia in the form of hypertriglyceridemiaoccurs more frequently in patients on therapy with the new generationof antipsychotics compared to patients treated with conventionaltherapy. Hypercholesterolemia as a form of dyslipidemia hadnot been proven as significantly frequent during the therapy withnew antipsychotics in relation to classical antipsychotic treatment