Nanogold – Biological effects and occupational exposure levels

摘要

Nanogold has different properties and biological activity compared to metallic gold. It can be applied in many fields, such as medicine,laboratory diagnostics and electronics. Studies on laboratory animals show that nanogold can be absorbed by inhalation andingestion. It can penetrate deep into the epidermis and dermis, but there is no evidence that it is absorbed through the skin. Goldnanoobjects accumulate mainly in the liver and spleen, but they can also reach other internal organs. Nanogold can cross theblood–brain and blood–placenta barriers. Toxicokinetics of nanogold depends on the particle size, shape and surface charge. Inanimals exposure to gold nanoparticles via inhalation induces slight changes in the lungs. Exposure to nanogold by the oral routedoes not cause adverse health effects in rodents. In animals after injection of gold nanoobjects changes in the liver and lungs wereobserved. Nanogold induced genotoxic effects in cells, but not in animals. No adverse effects on the fetus or reproduction werefound. There are no carcinogenicity studies on gold nanoparticles. The mechanism of toxicity may be related to the interaction ofgold nanoobjects with proteins and DNA, and it leads to the induction of oxidative stress and genetic material damage. The impactof nanostructures on human health has not yet been fully understood. The person, who works with nanomaterials should exerciseextreme caution and apply existing recommendations on the evaluation of nanoobjects exposure. The risk assessment should bethe basis for taking appropriate measures to limit potential exposure to nanometals, including nanogold. Med Pr 2017;68(4):545–556