Prognostic significance of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in patients with breast cancer

摘要

Introduction. The importance of understanding the biology of breast cancer is increasing and the determination of certain phenotypic characteristics of malignant cells, especially estrogen, progesterone and human epidermal growth factor receptor 2 expression, became a standard evaluation procedure in breast cancer patients, in order to provide prognostic information and best therapeutic options. Material and methods. This study included a total of 206 patients, all treated and followed up in the Daily Chemotherapy Hospital of the Health Center Vranje. Estrogen, progesterone and human epidermal growth factor receptor 2 statuses were evaluated in all patients to assess their potential impact on the progression-free and overall survival. Results. Two-thirds of patients were diagnosed at the early stage of the disease. Ductal carcinoma was the most common histological type. Patients with early stage breast cancer, with hormone-receptor positive and human epidermal growth factor receptor 2 negative tumors, had a significantly longer progression-free survival. Conclusion. Hormone-receptor and human epidermal growth factor receptor 2 status evaluation is still of great clinical importance with a reliable prognostic value in breast cancer patients.