Predictors of the therapeutic response of patients with influenza A (H1N1) 2009 infection

摘要

Aim To determine a predictive potential of biochemical and clinicalparameters, including independent predictors of the therapeuticoutcome in patients with H1N1 influenza.Methods In this retrospective study, 119 patients treated at theClinic for Infectious Diseases in Tuzla in the period July 2009 toFebruary 2010 were included. They were at the age of 1 month upto 80 years. The patients showed clinical, epidemiological and biochemicalparameters of the pandemic flu and they had also beenpositive for the virus A (H1N1), which was confirmed by the realtime polymerase chain reaction (RT-PCR).Results One hundred and nineteen patients were positive to thevirus A (H1N1), 60 (50.4%) were male, and 59 (49.6%) female patients.The average age of the patients was 26.74 years. The numberof patients with co-morbidity was 53 (44.5%). There were 71(59.7%) patients who had been admitted to the Intensive Care Unit.The complications of the flu had appeared in 45 (37.8%) patients.Pneumonia was recorded in 108 (90.8%), and reduced saturationin 62 (52.1%) patients. The highest number of cured patients wasin the group of patients who had received the oseltamivir within 48hours after the outbreak of the disease.Conclusion The age, reduced saturation with oxygen, duration ofthe hospitalization, pregnancy and overweight were independentpredictors of the severe form of the disease/lethal outcome. Foran optimal therapeutic outcome, it is important to apply antiviraltherapy as soon as possible