Levels of F1+2 prothrombin fragments and thrombin – antithrombin III (TAT) complexes in patients with dermatitis herpetiformis

摘要

Background: Dermatitis herpetiformis (DH) is a rare bullous disease of autoimmune etiology. It is an intestinocutaneous syndrome, in which vesicopapular cutaneous lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin fragment (granular IgA deposits present at the tops of dermal papillae and IgA – EmA present in the serum).Material/Methods: The studied group consisted of 33 patients with dermatitis herpetiformis – 23 males and 10 females aged 22–78 (mean age 44.7). In all the patients, the following parameters of bloodcoagulation systems were determined in the plasma Levels of prothrombin fragments 1+2 (F1+2), levels of thrombin – antithrombin III (TAT) complexes, antithrombin III activity (AT III).Results: In patients with dermatitis herpetiformis, the main level of F1+2 fragments amounted to 9.08 nmol/l, as compared with 1.14 nmol/l in the control group (the difference statistically significant,p