A new Pb(II)-based coordination polymer constructed from a semirigid tricarboxylate ligand: crystal structure and anti-lung cancer activity

摘要

Based on a semirigid tricarboxylate ligand 5-((4-carboxyphenoxy)methyl)benzene-1,3-dioic acid (H_(3)L), a new Pb(II)-based coordination polymer formulated as [Pb(HL)(H_(2)O)](H_(2)O) ( 1 ) was synthesized under solvothermal conditions and characterized by single-crystal X-ray structural analysis, power X-ray diffraction, and elemental analysis. Compound 1 is a two-dimensional layered structure formed by the connection of the one-dimensional Pb(II)-based secondary building unit chains with the partly deprotonated HL ligands, which are further extended into three-dimensional supermolecular structures through the H-bonds. Furthermore, the size of the as-prepared 1 could be downsized into the nano region through a simple ultrasonic method. Finally, the antilung cancer activities of 1 and the nanosized 1 have been probed via the MTT assay against three human lung cancer cell lines (A549, H1299, and PC9).