Positive transcription elongation factor b and its regulators in development

摘要

Positive transcription factor b (P-TEFb) has emerged as a general and essential factor to release RNA polymerase II from promoter-proximal pausing. Recruitment of P-TEFb by various master developmental regulators seems to be a common theme to allow for coordinated gene expression. The biological outcome is highly dependent on the cellular context as well as the nature of the transcription factor that recruits P-TEFb. Understanding the physiological functions of P-TEFb and its regulators will certainly have implications in human diseases such as cancer.