...
首页> 外文期刊>Frontiers in Immunology >Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review
【24h】

Pattern Recognition by Melanoma Differentiation-Associated Gene 5 (Mda5) in Teleost Fish: A Review

机译:黑色素瘤分化相关基因5(Mda5)在硬骨鱼中的模式识别:综述。

获取原文
           

摘要

Teleost fish, as with other vertebrates, rely on their innate immune system as a first line of defense against invading pathogens. A very important characteristic of the innate immune response is its ability to recognize conserved molecular structures, such as viral dsRNA and ssRNA. Mda5 is one of the three pattern recognition receptors (PRRs) that recognize cytoplasmic viral ligands. Teleost Mda5 is widely conserved among several fish species and possesses the same structural domains as those seen in their mammalian counterparts. Fish Mda5 has been shown to be capable of initiating an inflammatory response both in vitro (in different fish cell lines) and in vivo using synthetic viral analogs or virus. The interferon (IFN) pathway is triggered as a result of Mda5 activation, leading to the expression of type I IFNs, IFN- stimulated genes and pro-inflammatory cytokines. Although it is known that Mda5 acts as a receptor for virally-produced ligands, it has been shown more recently that it can also initiate an immune response against bacterial challenges. This review discusses recent advances in the characterization of teleost Mda5 and its potential role in antiviral and antibacterial immunity in teleost fish.
机译:硬骨鱼类与其他脊椎动物一样,依靠其先天免疫系统作为抵御入侵病原体的第一道防线。先天性免疫应答的一个非常重要的特征是其识别保守分子结构(如病毒dsRNA和ssRNA)的能力。 Mda5是识别细胞质病毒配体的三种模式识别受体(PRR)之一。 Teleost Mda5在几种鱼类中被广泛保存,其结构域与哺乳动物对应的结构域相同。已经证明,鱼Mda5能够使用合成的病毒类似物或病毒在体外(在不同的鱼细胞系中)和体内引发炎症反应。 Mda5激活可触发干扰素(IFN)途径,导致I型IFN,IFN刺激的基因和促炎细胞因子的表达。尽管已知Mda5充当病毒产生的配体的受体,但最近已显示它也可以启动针对细菌攻击的免疫应答。这篇综述讨论了硬骨鱼Mda5的表征及其在硬骨鱼抗病毒和抗菌免疫中的潜在作用的最新进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号