Chiral 1H NMR Analysis of Atropisomeric Quinazolinones with A Chiral Phosphoric Acid

摘要

A chiral phosphoric acid promoted enantioselective NMR analysis of atropisomeric quinazolinones was described, in which a variety of racemic arylquinazolinones such as afloqualone and IC-87114 were well recognized with up to 0.21 ppm ΔΔδ value. With this method, the optical purities of different nonracemic substrates can be fast evaluated with high accuracy.