Clinicopathologic Characteristics and Reproductive Outcomes of Patients with Borderline Ovarian Tumors (BOTs): A Single Institute Experience and A Review of the Literature

摘要

OBLECTIVES: In borderline ovarian tumor (BOT) cases, evaluating the therapy forms, the percentage?of recurrence and survival and the condition of fertility after conservative surgery, for those with a fertility?wish. STUDY DESIGN: The files, follow-up forms and pathological reports of 96 cases, diagnosed with BOT,?at our clinic, treated between 1994-2009, have been retrospectively evaluated. RESULTS: The mean age of the evaluated cases was 39.54±13.4. On the basis of histopathological?data, 46 cases (47.9%) had serous and 41 cases (42.7%) had mucinous, and 9 cases (9.4%) had other?histological subtypes. 88 cases were in stage I, 2 cases (2.1%) were in stage II and 6 cases (6.2%)?were in stage III. 89 (92.7%) cases were operated with laparatomy, 7 (7.3%) cases were operated with laparoscopy. In 52 cases (54.1%), conservative (fertility preserving) surgery was applied (27 cases?USO, 8 cases cystectomy, 17 cases USO-staging), in 44 cases (45.8%) radical surgery (in 32 cases,?complete staging, TAH-BSO in 11 cases, TAH-USO in 1 case). 26% of the cases (25 cases) underwent?postoperative adjuvant chemotherapy. In 39 cases with fertility wish, 8 pregnancy occured after therapy. In the follow-up, 10 cases (10.4%) had recurrence. The rate of recurrence was 4% (2/44) after radical?surgery and 15% (8/52) after conservative surgery. The general disease-free survival rate of the cases?(DFS) was 89.6%, and there was no significant difference between radical and conservative surgery in?view of DFS (95.45% vs 84.62%, p=0.97). CONCLUSION: In cases of borderline ovarian tumor, the best therapy is surgical debulking and the?post-operative recurrence rate is generally low. Although the recurrence risk in patients who underwent?conservative surgery is relatively higher, disease free survival rates are no different than those who had?radical surgery.