Different Doses of Arabic Coffee Improve Serum Lipid Profile, Uric Acid and Liver Enzymes of Experimental Rats

摘要

Coffee mixed with cardamom is a traditional beverage in Arab countries. The study aimed at investigates the effect of consumption of different levels of Arabic coffee on blood parameters concentration. Thirty two male rats (130±2.3 g) were divided into four equal groups (n=8), control, single dose of coffee (ACS), double dose of coffee (ACD), triple dose of coffee (ACT) and received daily an oral dose of 2 ml normal saline, 8.6, 17.1 and 25.7 mg Arabic coffee mixture/100 g BW respectively. The experiment continued for thirty days, at the end, rats were anesthetized and killed by exsanguinations. Blood samples were collected and used for determination of triglycerides, total cholesterol, HDLc, LDLc and VLDLc, urea, uric acid, ALT, and AST. Samples of kidneys, heart, and liver were collected for histopathological examinations. The results revealed that there was a decrease in body weight, cholesterol, LDLc, HDLc, uric acid concentration, and liver enzymes in rats received coffee at all levels. Liver enzymes were found to be significantly (P<0.05) lower in ACT than control and other groups. Histopathological results indicated no evidence of kidneys dysfunction or pathological alterations in other organs. In conclusion, the consumption of Arabic coffee, at different levels, could be beneficial for patients with hypercholesterolemia or hyperuricemia.