Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury first proposed a gastrointestinal mechanism for the overlap between depression, anxiety and skin conditions such as acne. Stokes and Pillsbury hypothesized that emotional states might alter the normal intestinal microflora, increase intestinal permeability and contribute to systemic inflammation. Among the remedies advocated by Stokes and Pillsbury were Lactobacillus acidophilus cultures. Many aspects of this gut-brain-skin unifying theory have recently been validated. The ability of the gut microbiota and oral probiotics to influence systemic inflammation, oxidative stress, glycemic control, tissue lipid content and even mood itself, may have important implications in acne. The intestinal microflora may also provide a twist to the developing diet and acne research. Here we provide a historical perspective to the contemporary investigations and clinical implications of the gut-brain-skin connection in acne.
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机译：自皮肤科医生约翰·斯托克斯（John H. Stokes）和唐纳德·皮尔斯伯里（Donald M. Pillsbury）首次提出胃肠道机制来缓解抑郁症，焦虑症和痤疮等皮肤疾病以来，已经过去了70多年。斯托克斯（Stokes）和皮尔斯伯里（Pillsbury）假设，情绪状态可能会改变正常的肠道菌群，增加肠道通透性并导致全身性炎症。斯托克斯和皮尔斯伯里提倡的补救措施包括嗜酸乳杆菌培养。这种肠脑皮肤统一理论的许多方面最近都得到了验证。肠道菌群和口服益生菌影响全身炎症，氧化应激，血糖控制，组织脂质含量甚至情绪本身的能力，可能对痤疮具有重要意义。肠道菌群也可能会扭曲正在发展的饮食和痤疮的研究。在这里，我们为痤疮的肠脑-皮肤连接的当代研究和临床意义提供了历史视角。
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