Controllable preparation and high properties of fluorescence and surface enhanced raman spectra encoded poly(glycidyl methacrylate) microsphere

摘要

Novel fluorescence and SERS encoded microspheres based on poly(glycidyl methacrylate) (PGMA) microsphereswere developed by a controllable approach. The microspheres were encoded by four fluorescence dyes and three surface enhancedRaman spectra (SERS) probes. Multiple dyes could be simultaneously incorporated into the PGMA microspheresfor encoding and the intensity of the fluorescence can be tuned by adjusting the feeding ratio. The PGMA microspheres werecoated by silver nanoparticles and encoded by single and multiple SERS reporters. The fluorescence and SERS joint encodedPGMA microspheres were fabricated. All the fluorescence encoding signals can be excited at 488 nm. The fluorescent andSERS signals of dual-mode microspheres could be obtained from two optical channels and non-overlapping of emissionspectra was observed in these encoded microspheres, which greatly increased the encoding capacity. The as prepared fluorescenceand SERS encoded microspheres possess stable and distinct spectral encoding signals, large encoding capacity.