Aspergillus fumigatus-specific immunoglobulin levels in BALF of CF patients

摘要

A lack of correlation between systemic and local IgE production at mucosal sites has been reported for allergic asthma [1–5], allergic rhinitis [6, 7] and chronic rhinosinusitis with nasal polyps [8–10]. In allergic asthmatics, local IgE production is higher than in nonallergic asthmatics [3] and high local IgE levels have been linked to the clinical phenotype. Interestingly, in cases of nasal polyps, local IgE targets mainly superantigens [8].IgE responses to Aspergillus fumigatus in cystic fibrosis lungs http://ow.ly/XXwv30furqsT. Eiwegger was involved in the conception, hypotheses delineation and design of the study. E. Nachbaur, Z. Szépfalusi, T. Eiwegger, J. Argeny, S. Kanolzer, K. Schmidthaler, P. Fucik, M. Go?a-H?pler, R. Crameri, A.G. Glaser, C. Rhyner and M. Debiasi were involved in acquisition, analysis and interpretation of the data. M. Go?a-H?pler and B. Pfaller were involved in analysis and writing the article. S. Renner, E. Nachbaur, Z. Szépfalusi and T. Eiwegger were involved in critical review of the manuscript.