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Spontaneous cord transection due to invasive aspergillus spondylitis in an immunocompetent child

机译:具有免疫功能的儿童因侵袭性曲霉性脊柱炎而自发横断

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Invasive spinal aspergillosis in an immunocompetent child is rare and often there is a considerable delay in diagnosis. A 13-year-old male child treated medically as tuberculosis of spine elsewhere for 1?year, came with complete paraplegia, dorsolumbar kyphosis and intermittently discharging sinus in the back. The child was taken up for surgical decompression and stabilization. Intraoperatively black granulomatous material was noted inside the canal extending anteriorly towards the vertebral body. There was complete cord transection with severe vertebral destruction and osteoporosis. The pathology and microbiology confirmed aspergillosis and the child was started on antifungal treatment. At further follow up, the infection was found to spread to the lung and caused further vertebral destruction. A change in the antifungal medication controlled further spread but failed to eradicate the infection at 2-year follow-up. In this patient, the delay led to extensive vertebral destruction with spine deformity and spontaneous cord transection. Retrospective review of the clinical and radiological findings suggests that this complication could have been prevented if these findings were carefully interpreted. In this era of transplantation and increase in use of immunosuppressive drugs the authors suggests having fungal infection as a differential diagnosis for infections of the spine...
机译:具有免疫功能的儿童中的侵袭性脊柱曲霉病很少见,并且诊断时常有相当大的延迟。一名13岁的男孩在医学上被视为其他地方的脊柱结核病长达1年,伴有完全的截瘫,背脊柱驼背畸形并间歇性地排泄了鼻窦。该孩子因手术减压和稳定而被收住。术中发现管内黑色肉芽肿物质向前向椎体延伸。脊髓完全横断,严重破坏椎骨和骨质疏松。病理学和微生物学证实曲霉菌病,该孩子开始接受抗真菌治疗。在进一步的随访中,发现感染扩散到肺部并引起椎骨进一步破坏。抗真菌药物的改变控制了进一步的扩散,但在2年的随访中未能根除感染。在该患者中,延迟导致脊椎畸形和自发性横切的广泛椎体破坏。对临床和放射学发现的回顾性研究表明,如果仔细解释这些发现,可以避免这种并发症。在这个移植和免疫抑制药物使用不断增加的时代,作者建议将真菌感染作为脊柱感染的鉴别诊断...

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