Giant cell tumors of the sacrum—a nationwide study on midterm results in 26 patients after intralesional excision

摘要

PurposeEvaluation of recurrences, complications and function at mid-term follow-up after curettage for sacral giant cell tumor (GCT).MethodsWe retrospectively studied all 26 patients treated for sacral GCT in the Netherlands (from 1990 to 2010). Median follow-up was 98 (6–229) months. All patients underwent intralesional excision, 21 with local adjuvants, 5 radiotherapy, 3 IFN-α, 1 bisphosphonates. Functional outcome was assessed using Musculoskeletal Tumor Society (MSTS) score. Statistics were performed with Kaplan–Meier, Cox regression, log rank and Mann–Whitney U.ResultsRecurrence rate was 14/26 after median 13 (3–139) months and was highest after isolated curettage (4/5). Soft tissue masses 10?cm increased recurrence risk (HR?=?3.3, 95?% CI?=?0.81–13, p?=?0.09). Complications were reported in 12/26 patients. MSTS was superior in patients without complications (27 vs. 21; p?=?0.024).ConclusionRecurrence rate for sacral GCT was highest after isolated curettage, indicating that (local) adjuvant treatment is desired to obtain immediate local control. Complications were common and impaired function...