Pulmonary endarterectomy in the management of chronic thromboembolic pulmonary hypertension

摘要

Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension; resulting from fibrotic transformation of pulmonary artery clots causing chronic obstruction in macroscopic pulmonary arteries and associated vascular remodelling in the microvasculature.Pulmonary endarterectomy (PEA) offers the best chance of symptomatic and prognostic improvement in eligible patients; in expert centres; it has excellent results. Current in-hospital mortality rates are <5% and survival is >90% at 1xe2x80x85year and >70% at 10xe2x80x85years. However; PEA; is a complex procedure and relies on a multidisciplinary CTEPH team led by an experienced surgeon to decide on an individual's operability; which is determined primarily by lesion location and the haemodynamic parameters. Therefore; treatment of patients with CTEPH depends largely on subjective judgements of eligibility for surgery by the CTEPH team.Other controversies discussed in this article include eligibility for PEA versus balloon pulmonary angioplasty; the new treatment algorithm in the European Society of Cardiology/European Respiratory Society guidelines and the definition of an xe2x80x9cexpert centrexe2x80x9d for the management of this condition.