Study of Osmotic Fragility Status of Red Blood Cell in Type II Diabetes Mellitus Patients

摘要

Diabetes Mellitus (DM) is one of the most prevalent non-communicable diseases in the world. Cell membrane injury is an important mechanism for pathophysoilogical changes in DM. Osmotic fragility (OF) status of Red blood cell (RBC) in hyperglycemic patients is expected to be increased. This study was conducted in Chittagong medical college hospital and Chittagong Diabetic Hospital from January 2015 to December 2015. 100 newly diagnosed (duration a?¤ 3 years) type II diabetes mellitus patients (Fasting blood glucose is a?￥7 mmol/L) were selected as cases. Age, sex and BMI matched 100 healthy subjects were included as control. OF of RBC was measured by traditional method with a series of hypotonic solution of NaCl of different strength in twelve test tubes numbered serially. The relationship of OF with Fasting blood sugar (FBS) and two hours post prandial blood sugar (2 HPPBS) were evaluated. Unpaired Student a??ta?? test and Pearsona??s correlation coefficient test were done for statistical analysis. p value.