Use of soy isoflavones on hormone replacement therapy during climacteric

摘要

Menopause is the physiological stage of women's lives, which occurs in the transition from reproductive to non-reproductive phase. During this period, physiological and clinical changes may occur due to the decline of estrogen production by the ovaries. In expectation of a better quality of life during this period, women seeking hormone replacement therapies that can minimize the unpleasant symptoms of menopause. The large number of women with contraindications to hormone replacement with synthetic estrogens boosted research on the constituents of plants with phenolic structure, especially phytoestrogens. Soy isoflavones have the ability to bind to estrogen receptors in several human cells and can act as estrogen, antiestrogen and antioxidant. The aim of this study is to determine the use of soy isoflavones on hormone replacement therapy in the climacteric period, thus presenting its activities in relieving symptoms.