首页>
外国专利>
Combine the women's climacteric and postclimacteric period of corporin and antiestrogenic antagonist and local antagonistic effect for hormone replacement therapy
Combine the women's climacteric and postclimacteric period of corporin and antiestrogenic antagonist and local antagonistic effect for hormone replacement therapy
展开▼
机译:结合女性更年期和更年期后的Corporin和抗雌激素拮抗剂以及局部拮抗作用进行激素替代治疗
展开▼
页面导航
摘要
著录项
相似文献
摘要
PCT No. PCT/EP94/03408 Sec. 371 Date Jul. 5, 1996 Sec. 102(e) Date Jul. 5, 1996 PCT Filed Oct. 17, 1994 PCT Pub. No. WO95/11013 PCT Pub. Date Apr. 27, 1995This invention describes the use of at least one compound having a progesterone-antagonistic (PA) action and at least one compound having an antiestrogenic (AOE ) action with a simultaneous partial agonistic action for the production of pharmaceutical agents for hormone substitution therapy (HRT) for perimenopausal and postmenopausal women. In the case of combined use of progesterone antagonist and antiestrogen, the stimulation of the endometrium by the progesterone antagonist that is caused by its partial agonistic action when an antiestrogen is used by itself is inhibited. For example, a pharmaceutical agent according to the invention contains onapristone (progesterone antagonist) and tamoxifen (antiestrogen).
展开▼