Evaluation of antitumour action of Ganoderma lucidum extract in hepatocarcinoma mice

摘要

The present study shows the protective effects of the?Ganoderma lucidum?aqueous crude extract (GLE) against mice liver cancer. The mice were randomized into four groups, namely, controls and tumor bearers that were?G. lucidum?extract- treated or untreated. Tumor bearers were inoculated intraperitoneally (ip) with 108 Yoshida AH-130 ascites hepatoma cells, whereas the controls received saline alone. The treatment began 1 day after tumor cell inoculation, and continued for 14 days. Administration of?G. lucidum?extract reduced the tumour weight of?G. lucidum-treated groups in a dose dependent way (1.627 ± 0.135, 1.142 ± 0.144 versus 2.163 ± 0.316) as compared to model control group. The inhibition rate was 24.84, and 47.31 by?G. lucidum?extract administration at concentrations of 200 and 400 mg/kg body weight, respectively. Results of this investigation justify continuing with further studies of?G. lucidum?extract components to develop chemoprevention strategies as an option in the treatment of cancer.