Formulation of propranolol hydrochloride controlled release tablets: Effect of surfactant charge and mechanisms of drug release

摘要

Controlled release drug formulation is a very important branch in pharmaceutical industry and attracts a lot of research and investments. Eudragit RL100 and sodium carboxymethylcellulose (NaCMC) are used in drug formulation due to their good coating properties. Here, we studied propranolol hydrochloride formulation with anionic polymer Eudragit RL100 alone and with other additives (lactose, sorbitol, dextrose). The formulation was also studied with Eudragit RL 100 and sodium carboxymethyl cellulose (NaCMC) with different concentrations and with other surfactants (Sodium lauryl sulfate, Sodium taurcholate, Cetrimide, Cetylpiridiniumc chloride and Betaine). The results showed that propranolol hydrochloride was completely released in less than four hours when the tablets were prepared from Eudragit RL100 alone or with lactose, sorbitol or dextrose. In contrast, when the tablets were prepared with Eudragit RL100 and NaCMC, a controlled release rate of the drug was observed. The kinetics and mechanism(s) of the drug release were discussed.