Development of in vitro-in vivo correlation for pharmacokinetic simulation

Ghulam Murtaza; Saira Azhar; Ayisha Khalid; Bushra Nasir; Muhammad Ubaid; Muhammad Khurran Shahzad; Fatima Saqib; Iftikhar Afzal; Sobia Noreen; Muhammad Tariq; Tahir Ali Chohan; Abdul Malik

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Development of in vitro-in vivo correlation for pharmacokinetic simulation

机译：药代动力学模拟中体内外相关性的发展

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This article presents a comprehensive overview of systematic procedure for establishing and validating an?in vitro?-?in vivo?correlation (IVIVC) level A, B, and C. It encompasses all experimental, statistical and mathematical concepts of IVIVC development and its validation. A Level A IVIVC is an important mathematical tool that can help to save time and cost during and after the development of a formulation.

机译：本文对建立和验证“体外”-“体内”相关性（IVIVC）A，B和C级的系统过程进行了全面概述。它涵盖了IVIVC开发及其验证的所有实验，统计和数学概念。 IVIVC A级是重要的数学工具，可以帮助您在配方开发期间和之后节省时间和成本。

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来源
《African Journal of Pharmacy and Pharmacology》 |2012年第4期|共7页
作者
Ghulam Murtaza; Saira Azhar; Ayisha Khalid; Bushra Nasir; Muhammad Ubaid; Muhammad Khurran Shahzad; Fatima Saqib; Iftikhar Afzal; Sobia Noreen; Muhammad Tariq; Tahir Ali Chohan; Abdul Malik;
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正文语种
中图分类药学;
关键词
BioavailabilitycorrelationdissolutionpredictabilityWagner-Nelson equation;

机译：生物利用度相关度溶解度可预测性Wagner-Nelson方程;

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1. Development of in vitro-in vivo correlation for pharmacokinetic simulation [J] . Ghulam Murtaza, Saira Azhar, Ayisha Khalid, African Journal of Pharmacy and Pharmacology . 2012,第4期

机译：药代动力学模拟中体内外相关性的发展
2. Novel extended in vitro-in vivo correlation model for the development of extended-release formulations for baclofen: From formulation composition to in vivo pharmacokinetics [J] . Kim Tae Hwan, Bulitta Jurgen B., Kim Do-Hyung, International Journal of Pharmaceutics . 2019,第期

机译：在体内体内相关模型中延伸的新型延长释放制剂的Baclofen：从体内药代动力学中的配方组合物
3. Modeling double peak phenomenon and in vitro-in vivo correlation (IVIVC) in pharmacokinetics (PK) for Clinical trial simulation (CTS) of virtual bioequivalence (BE) studies [J] . Feng Kairui, Leary Robert H., Dunlavey Michael, Journal of pharmacokinetics and pharmacodynamics . 2018,第Suppla期

机译：模拟双峰现象和体内相关（IVIVC）在药代动力学（PK）中的虚拟生物等效（BE）研究的临床试验模拟（CTS）
4. An in vitro-in vivo correlation from a ringcap~TM human pharmacokinetic study [C] . D.Dickason, G.Grandolfi, E.Rotty, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：RingcapTM人类药代动力学研究的体内外相关性
5. Using an in vitro-in vivo Correlation for the 'Bioequivalence by Design' Development of an Immediate Release Carbamazepine Product [D] . Steinbach, Douglas G. 2019

机译：使用vivo-invo相关性的“设计”开发立即释放卡马西妥产品的“生物等效”
6. In vitro-in vivo Pharmacokinetic correlation model for quality assurance of antiretroviral drugs [O] . Ricardo Rojas Gómez, Piedad Restrepo Valencia 2015

机译：体外抗逆转录病毒药物质量保证的药代动力学相关模型
7. Defining Fractional Inhibitory Concentration Index Cutoffs for Additive Interactions Based on Self-Drug Additive Combinations, Monte Carlo Simulation Analysis, and In Vitro-In Vivo Correlation Data for Antifungal Drug Combinations against Aspergillus fumigatus [O] . Meletiadis, J., Pournaras, S., Roilides, E., 2010

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Development of in vitro-in vivo correlation for pharmacokinetic simulation

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