Determination of the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) for a novel antibiotic

摘要

A novel antibiotic had a wide range of antibacterial spectrum. It was very stable to heat and to acid and alkali. In addition, the effects of storage on the antibiotic had not been observed even after it had been placed in a 37°C thermostat for up to four weeks. The MICs for the antibiotic against eleven strains of bacteria had been determined. Also, the determinations of the minimum bactericidal concentrations (MBCs) against four bacteria were conducted. The antibiotic-producer (Bacillus?subtilis) was no better in tolerating its own antibiotic than all the non BS-producers tested.