A small structure deep inside the brain, called the mediodorsal thalamus, is a critical part of a brain network that is important for learning new information and making decisions. However, the exact role of this brain area is still not understood, and there is little evidence showing that this area is actually needed to make the best choices. To explore the role of this area further, Chakraborty et al. trained macaque monkeys to choose between three colorful objects displayed on a touchscreen that was controlled by a computer. Some of their choices resulted in the monkeys getting a tasty food pellet as a reward. However the probability of receiving a reward changed during testing, and in some cases, reversed, meaning that the highest rewarded object was no longer rewarded when chosen and vice versa. While at first the monkeys did not know which choice was the right one, they quickly learned and changed their choices during the test according to which option resulted in them receiving the most reward. Next, the mediodorsal thalamus in each monkey was damaged and the tests were repeated. Previous research had suggested that such damage might result in animals repeatedly choosing the same option, even though it is clearly the wrong choice. However, Chakraborty et al. showed that it is not as simple as that. Instead monkeys with damage to the mediodorsal thalamus could make different choices but they struggled to use information from their most recent choices to best guide their future behavior. Specifically, the pattern of the monkeys’ choices suggests that the mediodorsal thalamus helps to quickly link recent choices that resulted in a reward in order to allow an individual to choose the best option as their next choice. Further studies are now needed to understand the messages that are relayed between the mediodorsal thalamus and interconnected areas during this rapid linking of recent choices, rewards and upcoming decisions. This will help reveal how these brain areas support normal thought processes and how these processes might be altered in mental health disorders involving learning information and making decisions.
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