Anti-Hypertensive Effects of Amlodipine and Enalapril in Combination with Atorvastatin in Hypertensive Dyslipidemic Patients

摘要

OBJECTIVES: To compare the antihypertensive effect of Enalapril and Amlodipine along with Atorvastatin inhypertensive dyslipidemic patients.STUDY DESIGN: Prospective and descriptive case study.PLACE AND DURATION: Study was conducted by the Department of Pharmacology & Therapeutics,LUMHS, Jamshoro at Red Crescent hospital, Latifabad, Hyderabad, Pakistan from 2007 to 2009.METHODS: One hundred (100) essential hypertensive, dyslipidemic patients were enrolled in the study.Protocol was approved by ethical committee. After taking written consent patients were divided into twogroups (A & B), each comprising 50 patients. Group A received Enalapril 10mg in the morning along with20mg Atorvastatin at bed time while group B received 5mg of Amlodipine in morning along with 20mg ofAtorvastatin at bed time. Blood pressure and lipid profile were done at the start (Baseline) and after 3 months(end of study) by mercury sphygmomanometer. Results were compared and analyzed statistically by usingSPSS-V16 at the end.RESULTS: At the end of the study when both groups were compared for antihypertensive effects. It wasobserved that the both the antihypertensive drugs have significantly lowered the blood pressure separatelybut when the effects were compared for both groups there was no significant change at the end of study.Enalapril reduced mean systolic blood pressure from 155.7 + 16.38mmHg at baseline to 140.1 + 8.36 mmHgand diastolic blood pressure to 93.6 + 5.81mmHg to 82.6 + 10.65 mmHg (P value 0.001). Amlodipine reducedthe systolic blood pressure from 157 + 16.72 mmHg to 142.1 + 9.37 mmHg and diastolic blood pressure from95.6 + 7.11mmHg to 81.4 + 11.06 mmHg (P value 0.001).Mean systolic blood pressure after treatment in group A was 140.1 + 8.36 mmHg and in group B was 142.1 +9.37 and mean diastolic blood pressure in group A and B after treatment was 82.6 + 10.65 mmHg and 81.4 +11.06 mmHg respectively (P value 0.58).CONCLUSION: Both drugs individually reduced the systolic and diastolic blood pressure significantly butwhen compared, there was no significant change noted and both were equally effective.