Menopause is a period of women’s lives with changes and symptoms that affect their work, sleep and quality of life. Therefore, it is important to overcome these symptoms. Objectives: The aim of the present study was to compare the effects of Calci soya balance and Vitagnus on menopausal symptoms. Patients and Methods: This double-blinded controlled trial study was performed in public health centers of Tehran University of Medical Sciences (2011-2012). Seventy postmenopausal women with menopausal symptoms were randomly divided into two groups of treatments with Vitagnus and Calci soya balance. Data were collected using interviews, answering Cooperman’s index questionnaires before four and eight weeks after the treatment. Descriptive and analytic statistics were used for analyzing the data. Results: In both groups, Wilcoxon test showed a significant decrease in the mean of Cooperman’s menopausal index as well as after four and eight weeks of treatment (P = 0.000). Mann-Whitney test did not show any significant differences between the two groups, before and after four and eight weeks of treatment. Conclusions: The results showed that both Vitagnus and Calci soya balance were effective on reduction of menopausal symptoms to a similar extent and medical community can administer each of these two drugs based on patients’ conditions and costs.
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