Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver

H Quesada; J M del Bas; D Pajuelo; S Díaz; J Fernandez-Larrea; M Pinent; L Arola; M J Salvadó; C Bladé

首页> 外文期刊>International Journal of Obesity >Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver

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Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver

机译：葡萄籽原花青素可纠正大鼠高脂饮食引起的血脂异常，并抑制肝脏中控制脂肪形成和VLDL组装的基因

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Objective:To determine whether proanthocyanidins can protect against dyslipidemia induced by a high-fat diet (HFD) and to address the mechanisms that underlie this hypolipidemic effect.

机译：目的：确定原花青素是否可以预防高脂饮食（HFD）引起的血脂异常，并探讨造成这种降血脂作用的机制。

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《International Journal of Obesity》 |2009年第9期|共6页
作者
H Quesada; J M del Bas; D Pajuelo; S Díaz; J Fernandez-Larrea; M Pinent; L Arola; M J Salvadó; C Bladé;
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中图分类营养学;
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1. Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet. [J] . Baiges I, Palmfeldt J, Blade C, Molecular & cellular proteomics: MCP . 2010,第7期

机译：根据饲喂高脂饮食的大鼠的肝脏蛋白质组学，葡萄籽原花青素可减少脂肪生成。
2. Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats [J] . Bao L, Cai XX, Dai XQ, Food & Function . 2014,第8期

机译：葡萄籽原花青素可通过激活低剂量链脲佐菌素和高碳水化合物/高脂饮食诱导的糖尿病大鼠中的过氧化物酶体增殖物激活的受体-γ共激活因子1α来减轻足细胞损伤
3. Grape seed proanthocyanidin extracts prevent hyperglycemia-induced monocyte adhesion to aortic endothelial cells and ameliorates vascular inflammation in high-carbohydrate/high-fat diet and streptozotocin-induced diabetic rats [J] . Zhang Zhaofeng, Li Yujie, Li Yong International Journal of Food Sciences and Nutrition . 2016,第1a8期

机译：葡萄籽原花青素提取物可防止高糖/高脂饮食和链脲佐菌素诱导的糖尿病大鼠中高血糖诱导的单核细胞粘附于主动脉内皮细胞并改善血管炎症
4. Mitochondrial DNA copy number and citrate synthase activity in nonalcoholic fatty liver disease induced in rats by a high-fat plus fructose diet fortified or not with dehydroepiandrosterone (DHEA) [C] . ANGELA MARIA LEZZA, PIERLUIGI CASSANO, RAFFAELLA MASTROCOLA, WSEAS International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2009

机译：在大鼠诱导的高醇脂肪肝病中，用高脂肪加果糖饮食强化或不含脱氢食品（DHEA）的线粒体DNA拷贝数和柠檬酸合酶活性
5. Modulation of CYP3A activity by dexamethasone and grape seed proanthocyanidin extract and their combinations in rat liver in vivo [D] . Sengupta, Amritaparna 2009

机译：地塞米松和葡萄籽原花青素提取物及其组合在大鼠肝脏中对CYP3A活性的调节
6. Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet [O] . Isabel Baiges, Johan Palmfeldt, Cinta Bladé, 2010

机译：饲喂高脂饮食的大鼠肝脏蛋白质组学研究表明葡萄籽原花青素可减少脂肪生成
7. Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet* [O] . Baiges, Isabel, Palmfeldt, Johan, Bladé, Cinta, 2010

机译：饲喂高脂饮食的大鼠肝脏蛋白质组学表明，葡萄籽原花青素可减少脂肪生成*
8. Lipogenesis and Glyceride Synthesis in the Rat: Response to Diet and Exercise. [R] . Askew, E. W., Dohm, G. L., Doub, W. H., 1974

机译：大鼠脂肪生成和甘油合成：对饮食和运动的反应。

Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver

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