SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF SOME N-SUBSTITUTED DERIVATIVES OF 6-FLUORO-1-METHYL-4-OXO-7-(PIPERAZIN-1-YL)-4H-[1,3]THIAZETO[3,2-A]QUINOLINE-3-CARBOXYLIC ACID

摘要

Objective: N-substituted derivatives of 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-4H-[1, 3] thiazeto [3, 2-a] quinoline-3-carboxylic acid: Synthesis and antibacterial activity. Me thods: In the present study N-substituted derivatives of 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid were prepared by using Triethylamine and DMF. This procedure was modified by adding tetra butyl ammonium bromide (TBAB) to facilitate completion in few reactions. Other reactions which did not proceed in both the aforementioned ways were facilitated by the use of Morwet-D425. All the new title compounds were characterized by their spectral data and were screened for antibacterial activity. Results: Some of the reported compounds were synthesized using the process disclosed by us in U.S.Pat.No.8, 410,268B2. In our present work, we have achieved good yields and purity. Many compounds exhibited substantial antibacterial activity. Conclusion: It can be inferred that the title compounds with substituted phenyl and quinoline rings exhibited comparable antibacterial activity with respect to the standard