Comparison of the Therapeutic effects of Nano-essence of Medical herb Artemisia sieberi with the ointment of Ketoconazole in guinea pig infected by Microsporum canis

摘要

Essences have well known properties. Transforming a drug to nano sized particles usually adds some additional potency to that drug. In this study we used Artemisia sieberi nano-essence to treat Microsporum canis induced dermatophytosis in guinea pig model. In vivo and In vitro methods were used to investigate the antifungal properties of nano-essence. Minimum inhibitory concentration of nano-essence was 0.3% to 2%. Treatment started 5 days after infection as 12 hours regimen until 45 days post infection. Both Ketoconazole and nano-essence groups had complete cure at day 40. Results show that this nano-essence is effective drug to treat M.canis induced dermatophytosis.