ANTI EPILEPTIC ACTIVITY OF SAPINDUS EMERGINATUS VAHL FRUIT EXTRACT IN PENTYLENETETRAZOLE INDUCED SEIZURE MODEL

摘要

Objective: Sapindus emerginatus (sapindaceae) is used as traditional Indian medicine to treat epilepsy. The purpose of the present study is to investigate the effect of methanol extract of Sapindus emerginatus (MESE) on neurochemical concentrations in rat brain after induction of seizure by Pentylenetetrazole (PTZ). Method: Method includes relationship between seizure activities and altered monoamines such as nor adrenaline, Dopamine, Serotonin and Gamma amino butyric acid in forebrain of rats in Pentylenetetrazole model. Result: In Pentylenetetrazole model, extracts (200 & 400 mg/kg) significantly restored the decreased levels of brain monoamines such as nor adrenaline, Dopamine, Serotonin and Gamma amino butyric acid. Conclusion: Thus, this study suggests that methanol extract of Sapindus emerginatus had increased the monoamine levels on rat brain, which were decreased due to the susceptibility to Pentylenetetrazole induced seizure in rats