ANTI-CONVULSANT ACTIVITY OF VARIOUS EXTRACTS OF LEAVES OF CALOTROPIS GIGANTEA LINN AGAINST SEIZURE INDUCED MODELS

摘要

Calotropis.gigantea.Linn..(Asclepiadaceae).a.widely.growing.plant.has.been.reported.to.possess.number.of.medicinal.properties..The.purpose.of.the.present.study.was.to.evaluate.scientifically.the.anticonvulsant.activity.of.Petroleum.ether,.Benzene,.Chloroform,.Methanol.and.Aqueous.extract.of.leaves.of.the.plant.C.gigantea.in.albino.Wistar.rats.on.electrically.and.chemically.induced.seizures..The.anti‐convulsant.activity.of.different.extracts.of. C.gigantea.leaves. was.studied.against. seizures. induced. by. maximal. electroshock.seizures.(MES).and.pentylenetetrazole.(PTZ)..There.was.no.difference.between.preventing.of.PTZ‐induced.death.and.MES‐induced.hind.limb.tonic.extension.(HLTE).in.methanolic.extract.comparing.to.control.groups..In.the.MES.test,.the.methanol.extract(180mg/kg.p.o).of. C.gigantea.leaves.showed.the.most.significant.(p.<.0.001).anticonvulsant.effect.by.decreasing.the.duration.of.HLTE,.clonus.and.also.the.duration.of.stupor.phase.than.other.extracts.when.compared.to.control.group.and.produced.68%.protection.in.rats..In.the.PTZ.test,.the.methanol.extract.(180.mg/kg.p.o). showed.a. highly. significant.(p. <. 0.001). effect. and.produced. 55%.protection.in.rats,.The.ED50.dose.of.Phenytoin.(25.mg/kg.i.p).was.used.as.standard..In.conclusion.it.was.realized.that.methanol.extract.(ED50.=.180.mg/kg.p.o).is.more.potent.than.other.extracts.in.showing.anti.seizure.effects