A VALIDATED RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND LORNOXICAM IN COMBINED TABLET DOSAGE FORM

摘要

A.simple,.accurate.and.precise.reverse.phase.high.performance.l iquid.chromatographic.method.for.the.simultaneous.estimation.of.Paracetamol.and.Lornoxicam.in.combined.tablet.dosage.form.has.been.developed.and.validated..Chromatographic.separation.was.carried.out.on.Jasco.HPLC.system.equipped.with.Grace.C1 8 .column.(150.mm×4.6.mm.i.d.).and.UV/VIS.detector.using.Acetonitrile:.0.04.mM.Potassium.hydrogen.phosphate.buffer.in.the.ratio.of.(60:40,.v/v).as.mobile.phase..at.a.flow.rate.of.1.0.mL/min.and.detection.was.carried.out.at.270.nm..The.retention.time.for.Paracetamol.and.Lornoxicam.was.found.to. be. 1.956.±.0.002. and. 3.171.±.0.018. min,.respectively..Results.were.linear.in.the.range.of.2‐12.μg/mL.for.both.the.drugs..The.method.has.been.successfully.applied.for.the.analysis. of. drugs. in. pharmaceutical. formulation.. Results. of. analysis. were. validated.statistically.and.by.recovery.studies