EVALUATON OF BARLEY (HORDEUM VULGARE) STARCH AS TABLET DISINTEGRANT

摘要

Dodonaea. viscosa.(Sapindaceae).leaves.are.traditionally. used.in. the.treatment.of.skin.diseases,.diarrohea,.colic.pain.etc..The.ethyl.acetate.extract.(DEA).and.methanolic.extract.(DME).of. Dodonaea.viscosa.leaves.were.administered.orally.at.different.doses.(200.and.400mg/kg.bw).to.normal.as.well. as. STZ‐diabetic. rats.. DME. produced. significant. hypoglycemi c.effect.in.normal.rats.after.6h.of.administration..After.acute.treatment.DME.400mg/kg. produced. marked. fall. (30.87%). after. 6h. of. administrati on.. DME. 200mg/kg. and. 400mg/kg. both. showed. improvement. in. glucose.tolerance..Treatment.of.diabetic.rats.for.28.days.with.DME.reduced.the.fasting.glucose.level.by.43.81%.than. their.pretreatment.level..It.brought.about.fall.in.level.of.total.cholesterol.by.36%.and.38.89%.and.HbA1c.by.29.44%.and.35.6%..The.increase.in.glycogen.level.was.found.to.be.68.97%.after.treatment.with.DME.400mg/kg.bw..It.also.normalized.the.elevated.level.of.MDA.in.diabetic.rats..DME.200mg/kg.and.400mg/kg.brought.about.the.decreased.level.of.GSH.to.near.normal..The.level.of.SGOT,.SGPT.were. also. found.to.be.decreased.which.is.comparable.to. the. standard..These.results.clearly.indicated.that.Dodonaea.viscosa.methanolic.extract.(DME).possess.antidiabetic.and.antioxidant.effect.in.diabetic.rats..