Immunohistochemical Expression of Fn14 in invasive Ductal Carcinoma (IDC) and its Correlation with Clinical and Histopathological parameters of Human Breast cancer

摘要

Fibroblast growth factor-inducible 14 (Fn14), is a member of the tumor necrosis factor receptor superfamily that normally expressed in healthy tissues, but its expression is increased in injured tissue where it thought to play role in tissue remodeling. Over expression of Fn14 expression is reported in many tumors, which is why this protein is under consideration as a therapeutic target in oncology.The aim of the present work was to investigate the expression of Fn14 as a novel prognostic biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. Immunohistochemical technique was used to examine the expression of Fn14 in normal, benign as well as in IDC. Present results showed higher expression of Fn14 in IDC comparing to normal and benign breast tissues. Statistical analysis showed significant correlations between the expression of Fn14 and histological tumor grade, lymph node metastasis (LNM) and HER2eu. Negative correlation was noticed between the expression of Fn14 and both ER and PR status. Current results suggest that Fn14 protein may be a valuable prognostic and therapeutic marker inhuman IDC pateints.