PREPARATION AND CHARACTERIZATION OF IN SITU CROSS–LINKING ALGINATE/POLYETHYLENE GLYCOL 6000 BLEND MICROPARTICLES FOR CONTROLLING SALBUTAMOL SULPHATE PULMONARY DELIVERY

摘要

Objective: The goal of the present work was loading salbutamol sulphate into microparticles consist of sodium alginate/polyethylene glycol 6000 blend to deliver it locally into the respiratory system. Method: Procedure employed involves melting, blending, freezing, powdering and sieving to get microparticles suitable for inhaling. Results: Formula consists of 1:1 hydrophilic polymers ratio was showing the least drug percent release (85.239% after 6h). The dug release kinetic was best fit with Korsmeyer– Peppas model and the drug release mechanism was Fickian. Both cross–linking agent (calcium chloride) and sodium alginate amount affect the particle size and the particle surface feature and was proved by the optical and electron microscopes. Fourier transform infrared spectroscopy revealed that some peaks disappearance and/or shifting may be due to H–bonding between the drug and either and/or both polymers, whereas; the X–ray diffraction spectroscopy shows that the amorphous nature of sodium alginate affects peak clarity of the drug. Out of eleven formulations, F6 provide the optimum drug sustained release. Conclusion: A hydrophilic drug release can be controlled and prolonged by loading it within a hydrophilic matrix