COMPARATIVE EVALUATION OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT FOR PROMOTING NIMESULIDE DISSOLUTION FOR FAST DISSOLVING TECHNOLOGY

摘要

The.purpose.of.this.research.was.to.develop.fast.dissolving.tablets.of.Nimesulide.containing.natural.Lepidium.sativum.(family:.Cruciferae).known.as.asaliyo. and. widely. used. as. herbal. medicine. and. pharmaceutical. excipient. as. disintegrating. agent.. The. mucilage. was. extracted. from. seeds. of.Lepidium. sativum.and.was.used. to.develop. the.fast.dissolving.tablet. of. Nimesulide..The.extracted. mucilage.was.characterized.for. Weight.loss. on.drying,.Particle.size,.pH.of.solution,.Swelling.ratio,.Bulk.and.tapped.density,.Compressibility.index,.Viscosity.and.Angle.of.repose..The.disintegration.property.of.extracted.mucilage.in.FDTs.was.compared.with.widely.used.superdisintegrants.like.Sodium.starch.glycolate.(SSG),.Kyron.T314,.Ac.Di.Sol..The.prepared.FDTs.were.evaluated.for.Uniformity.of.weight,. Hardness,. Tablet. thickness,. Percentage. friability,. Wetting. time,. In-vitro.disintegration.time.and. In-vitro.dissolution..From.the.study,.it.was.concluded.that.higher.dissolution.of. tablet. could. be.obtained. when. mucilage.concentration.is.10%.and.also.the.mannitol.concentration.was.10%..Promising.batch.(M5).exhibited.better.drug.dissolution.(79.9%).after.30.min.than.the.other.tablets..The.disintegration.and.mean.dissolution.time.for.batch.M5.was.17.sec.and.5.27.sec.respectively.is.better.than.other.tablet.prepared.from.other.synthetic.disintegrating.agent...