QUANTITATIVE ESTIMATION OF ASPIRIN IN TABLETS AND BULK SAMPLE USING METFORMIN HYDROCHLORIDE AS HYDROTROPIC AGENT

摘要

Concentrated. aqueous. solutions. of. a. large. number. of. hydrotropic.agents.viz..sodium.benzoate,.sodium.salicylate,.niacinamide,.urea.,.sodium.citrate.and.sodium.acetate.have.been.employed.to.enhance.the.aqueous.solubilities. of. poorly. water‐soluble. drugs.. Various. organic. solvents. like. methanol,. chloroform,. dimethyl.formamide.and.ethanol.have.been.employed.for.solubilization.of.poorly.water‐soluble.drugs.to.conduct.their.titrimetric.analyses..Drawbacks.of.organic.solvents.include.the ir.higher.costs,.toxicities.and.pollution..There.was.more.than.15.times.enhancement.in.the.aqueous.solubility.of.aspirin.(a.poorly.water‐soluble.drug).in.1.5.M.metformin. hydrochloride.solution. (an. inexpensive. antidiabetic.drug,.used.here.as.hydrotropic.agent).as.compared.to.its.aqueous.solubility..Therefore,.it.was.thought.worthwhile. to. employ. 1.5. M. metformin.hydrochloride. solution. to. solubilize. aspirin. for. its. titrimetric. analysis.. Back. titration. methods. of.Pharmacopoeia.are.time.consuming..Proposed.method.is.rapid.and.involves.direct.titration.