ENHANCEMENT OF DISSOLUTION OF NIFEDIPINE BY SURFACE SOLID DISPERSION TECHNIQUE

摘要

The. main. objective. of. the. study.was.to. enhance. the. dissolution. of.nifedipine,.a. poorly. water.soluble. drug. by. surface. solid.dispersion.technique.using.different.carriers.and.to.study.the.effect.of.each.carrier.on.the.in.vitro.dissolution.profile..The.formulations.were.optimized.in.the.preliminary.trials. by.using.various. ratios.of.different.carriers. like.kyron.T‐314,. croscarmellose.sodium,.crospovidone,.silicified.microcrystalline.cellulose. and.sodium.starch.glycolate..Resultant.formulations.were.evaluated.using.FTIR,.X‐ray.diffraction,.DSC,.GC,.SEM.and.in.vitro.dissolution..Solid.dispersion.with.kyron.T‐314.at.1:9.ratio.gave.good.release.when.compared.to.pure.drug.and.physical.mixtures..The.optimized.dispersion.was.formulated.in.to.sublingual.tablets.by.using.kyron.T‐314,.crospovidone,.croscarmellose.sodium.and.sodium.starch.glycolate.as.disintegrants.and.was.evaluated.for.friability,.hardness,.weight.variation,.disintegration.and.in.vitro.dissolution..The.sublingual.tablets.prepared.with.kyron.T‐314.as.disintegrant.gave.good.disintegration...