REVERSE PHASE ISOCRATIC HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND BECLOMETHASONE DIPROPIONATE IN ROTACAPS FORMULATION DOSAGE FORMS

摘要

A.new,.rapid.and.sensitive.RP.isocratic.HPLC.method.for.simultaneous. estimation. of.Salbutamol. Sulphate. and.Beclomethasone.Dipropionate. in.Rotacaps.formulation.has.been.developed..The.determination.was.performed. using.HPLC. system. with. an.octadecylsilane.column.and. a. solvent.system.comprising.of.water.and.Acetonitrile.in.the. volume.ratio. of.( 40:60. v/v)..The. detection. was.carried. out.using.a.UV.detector.set. at.230.nm.wavelength..The.method.was.validated.with.respect.to.the.linearity,.accuracy,.specificity.and.robustness..The.method.has.been.successfully.applied.for.analysis.of.drugs.in.Rotacaps.pharmaceutical.formulation.and.is.suitable.for.the.routine.quality.control.analysis..