MICROPARTICULATE DRUG CARRIERS: A PROMISING APPROACH FOR THE DELIVERY OF ANTI HIV DRUGS

摘要

Human immunodeficiency virus (HIV) is a retrovirus which causes acquired immuno deficiency syndrome (AIDS), a condition where immune system begins to fail in humans, leading to life‐threatening infections. Recent advance in highly active antiretroviral (ARV) agents has led to tremendous reduction of viral load in plasma, progression of infection and mortality from AIDS. Various classes of antiretroviral agents are available nowaday but unfortunately most of these drugs have poor physiochemical properties which result in poor absorption, undesirable side effect and accumulation of the drug at inappropriate sites. To overcome these drawbacks, particulate systems like microparticles have been introduced to improve the pharmacokinetic and pharmacodynamic properties of various types of antiretroviral drugs and targeting them to particular sites. To formulate microcarrier based systems, different polymers are used in the antiretroviral micro particulate drug delivery research to increase therapeutic activity and minimize side effects. Among the recent approaches of novel drug delivery system ,microparticulate drug carriers is found to be the most important one. The aim of this review is to discuss the need for novel drug delivery, advantages, recent development in microparticulate drug delivery system for antiretroviral drugs and challenges standing ahead