Objective: The main objective of the present study was to develop a polyherbal solid dosage formulation and to evaluate antioxidant properties with respect to vitamin-E. Methods: Polyherbal formulation was developed by using well documented medicinal plants, Amla, Withania and Tulsi. The extracts were prepared by using solvents like 60% ethanol for Amla, 50% ethanol for Withania and 99.9% ethanol for Tulsi. Formulation was evaluated by using different methods like nitric oxide scavenging activity, Free radical scavenging by DPPH method and scavenging of hydroxyl radical (Deoxyribose Method). Vitamin-E was used as standard. Results: The formulated polyherbal chewable tablet was proved to show pronounced invitro antioxidant activity and its percentage inhibition was at 200μg concentration found to be 96.34 of DPPH inhibition, 69.22 of Nitric oxide, and 36.00 of Hydroxyl radical effect. Conclusion: In conclusion, the present study shows that the polyherbal chewable tablet showed pronounced invitro antioxidant activity
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