SYNTHESIS, DOCKING AND BIOLOGICAL STUDIES OF THE LINEAR TETRAPEPTIDE PWPV-A POTENT INSECTICIDAL AGENT

摘要

Linear Tetrapeptide L-PWPV was designed and synthesized by solution phase peptide synthesis based on do ck score. The molecular docking studies of the designed tetrapeptide L-PWFV was carried out using Molegro Virtual Docker software for tumor cancer protein (1OLG). The linear tetrapeptide was synthesized by coupling protected amino acids (dipeptides) using EDC (ethyl-3-(N,N-dimethylamino)propyl carbodiimide) as coupling reagent. The compound was analyzed by FTIR, 1HNMR and MASS data and was subjected to antioxidant activity using 1,1-dipheny-2-picryl-hydrazil (DPPH) method and insecticidal activity by Morita et al method