SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF SOME SCHIFF BASES OF 2-AMINO-N-(P-ACETAMIDOPHENYL CARBOXAMIDO)- 4,5,6,7-TETRAMETHYLENE THIOPHENES

摘要

The novel 2-amino-N-(p-acetamidophenyl carboxamido)-4,5,6,7-tetramethylene thiophenes was synthesized by using versatile Gewald Reaction and the parent compound [SM-2] was reacted with different substituted aryl aldehydes to obtain the series of compound [SM-2a-l]. All the new title compounds were characterized by spectral data and were screened for antibacterial activity against two Gram-positive bacteria i.e. Staphylococcus aureus & Bacillus subtilus and two Gram-negative bacteria i.e. Escherichia coli & Klebsiella pneumoniae using Ampicillin and Norflaxacin as standard, each at a concentration of 50μg/0.1ml, adapting agar diffusion method. The compounds were also screened for their antifungal activity against two pathogenic fungi i.e. Candida albicans and Aspergillus niger using Miconazole nitrate as standard at a concentration of 50μg/0.1ml, adapting agar diffusion metho d