A STUDY OF ADVERSE DRUG REACTIONS IN PATIENTS ADMITTED TO INTENSIVE CARE UNIT OF A TERTIARY CARE TEACHING RURAL HOSPITAL

摘要

Adverse drug reactions (ADRs) are the common problems faced in the setups like ICU where the poly pharmacy is involved in treating the patients. Control of such events is possible if the culpable drug is kno wn or if it is identified and reported. However, reporting of adverse drug reactions still remains in its infancy for problems in many. Awareness about adverse drug reactions can decrease irrational use of medicines, poly pharmacy and adverse drug-drug interactions. A prospective, observational and non-interventional study was conducted over a period of 18 months in medical ICU of Dhiraj hospital, Piparia with the goal to highlight the responsibility of health care professionals in preventing, identifying, diagnosis, treating and reporting ADRs. The patients were monitored daily for ADRs. The data was analyzed for demographic parameters. The causality relationship between suspec ted drugs and the reactions were assessed by using various standard causality assessment scales. 1000 patients were enrolled for the study. Out of these 45 patients developed ADRs. Of these 27 males and 18 females developed ADRs showing male predominance (2.7%). The ADRs increased with inc reasing number of drugs administered. The drug class most commonly implicated with ADRs was antibiotics 24(53.33%).The system most commonly involved with an ADR was gastrointestinal tract 26.67%. Most commonly reported reaction were hypoglycemia (13.33%) and Rash (11.11%).